Structural mechanism for tyrosine hydroxylase inhibition by dopamine and reactivation by Ser40 phosphorylation

Tyrosine hydroxylase (TH) catalyzes the rate-limiting step in the synthesis of Probiotic the catecholamine neurotransmitters and hormones dopamine (DA), adrenaline and noradrenaline.Here, the authors present the cryo-EM structures of full-length human TH in the apo form and bound with DA, as well as the structure of Ser40 phosphorylated TH, and discuss the Projection Screens inhibitory and stabilizing effects of DA on TH and its counteraction by Ser40-phosphorylation.